My wife and I have annual passes to Great Smoky Mountain Railroad. We have ridden the Nantahala run dozens of times. It crosses a wonderful trestle bridge on the way to the Nantahala Outdoor Center. That trestle bridge was featured in the Sandra Bullock movie, Forces of Nature. Some of the cars were featured in the movie My Fellow Americans.
We finally got to take the Tuckaseegee run the other day. It runs past the spot where the train wreck for The Fugitive (1993) was filmed and the bus and train cars are still there. The Tuckaseegee run also has a nice tunnel though the Nantahala run has much better scenery.